Title:
吸着したポリペプチド含有分子を有する微粒子
Document Type and Number:
Japanese Patent JP4646516
Kind Code:
B2
Abstract:
Microparticles with adsorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(±-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide-containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens).
Inventors:
Oh Hagan, Derrick
Shin, Manmohan
Kazaz, Gina
Shin, Manmohan
Kazaz, Gina
Application Number:
JP2003569802A
Publication Date:
March 09, 2011
Filing Date:
February 20, 2003
Export Citation:
Assignee:
Novartis Bakushin's and Diagnostics, Incorporated
International Classes:
A61K47/34; A61K9/14; A61K9/16; A61K39/00; A61K39/02; A61K39/12; A61K39/21; A61K39/39; A61K47/48; A61P37/04; A61K9/00; C07K17/08
Domestic Patent References:
| JP2001511148A | ||||
| JP8505836A | ||||
| JP6340550A | ||||
| JP11508912A |
Other References:
CARRIO A. et al.,Journal of Controlled Release,1995年,Vol.37,p.113-121
JEONG Y. et al.,Journal of Applied Polymer Science,2001年,Vol.80,p.2228-2236
JEON H. et al.,International Journal of Pharmaceutics,2000年,Vol.207,p.99-108
JEONG Y. et al.,Journal of Applied Polymer Science,2001年,Vol.80,p.2228-2236
JEON H. et al.,International Journal of Pharmaceutics,2000年,Vol.207,p.99-108
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita