Title:
エナンチオマー的に純粋なミルタザピンの調製方法
Document Type and Number:
Japanese Patent JP4668184
Kind Code:
B2
Abstract:
The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with enantiomeric excess is formed by the ring closure of the compound of formula (II) with enantiomeric excess by treatment with a suitable acid in the absence of a solvent or a suitable combination of an acid and an organic solvent.
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Inventors:
Birinha, Johannes Hubertous
Juan de Fuen, Adrianis Antonius Marteinus
Chemperman, Heraldus Johannes
Juan de Fuen, Adrianis Antonius Marteinus
Chemperman, Heraldus Johannes
Application Number:
JP2006518216A
Publication Date:
April 13, 2011
Filing Date:
July 05, 2004
Export Citation:
Assignee:
Narmrose Fuennault Chap Organon
International Classes:
C07D471/14; C07D401/04; C07B53/00
Domestic Patent References:
| JP51122099A | ||||
| JP2001342188A | ||||
| JP2001049137A | ||||
| JP11222407A |
Foreign References:
| WO2000062782A1 | ||||
| US20030069417 |
Other References:
SELDITZ U,JOURNAL OF CHROMATOGRAPHY A,NL,ELSEVIER SCIENCE,1998年 4月17日,V803 N. 1-2,P169-177
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura