Title:
肺胞分化又は再生誘導剤
Document Type and Number:
Japanese Patent JP4668197
Kind Code:
B2
Abstract:
The present invention provides an agent comprising HGF for inducing differentiation of bone marrow cells into alveolar cells. The present invention also provides an HGF-containing agent for alveolar formation in pulmonary emphysema and the like in which alveoli are destroyed.
Inventors:
Yuji Kubo
Kota Ishizawa
Hidetada Sasaki
Toshikazu Nakamura
Kota Ishizawa
Hidetada Sasaki
Toshikazu Nakamura
Application Number:
JP2006527793A
Publication Date:
April 13, 2011
Filing Date:
March 07, 2005
Export Citation:
Assignee:
Tohoku Techno Arch Co., Ltd.
Kringle Pharma Co., Ltd.
Kringle Pharma Co., Ltd.
International Classes:
C12N5/078; A61K38/17; A61K38/18; A61K38/20; C12N5/07; C12N5/077; A61K38/00; A61P11/00; A61P43/00
Domestic Patent References:
| JP6172207A | ||||
| JP8268906A |
Other References:
SAKAMAKI YASUSHI ET AL,Hepatocyte Growth Factor Stimulates Proliferation of Respiratory,American journal of respiratory cell and molecular biology,2002年,Vol.26, No.5,p.525-533
MASON ROBERT J,Hepatocyte growth factor: The key to alveolar septation?,American journal of respiratory cell and molecular biology,2002年,Vol.26, No.5,p.517-520
DOHI,M. et al,Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis,American journal of respiratory and critical care medicine,2000年,Vol.162, No.6,p.2302-7
WARE LORRAINE B ET AL,Keratinocyte and hepatocyte growth factors in the lung,American journal of physiology,2002年,Vol.282, No.5,p.L924-L940
AKIYAMA,K.D. et al,Effect of hepatocyte growth factor on lung injury and development of clinical application,Chest,2001年,Vol.120, No.SUPPL,p.59S
LIU,X.L. et al,The protective effect of hepatocyte growth-promoting factor (pHGF) against hydrogen peroxide-induced acute lung injury in rats,Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan,2001年,Vol.34, No.2,p.92-102
MASON ROBERT J,Hepatocyte growth factor: The key to alveolar septation?,American journal of respiratory cell and molecular biology,2002年,Vol.26, No.5,p.517-520
DOHI,M. et al,Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis,American journal of respiratory and critical care medicine,2000年,Vol.162, No.6,p.2302-7
WARE LORRAINE B ET AL,Keratinocyte and hepatocyte growth factors in the lung,American journal of physiology,2002年,Vol.282, No.5,p.L924-L940
AKIYAMA,K.D. et al,Effect of hepatocyte growth factor on lung injury and development of clinical application,Chest,2001年,Vol.120, No.SUPPL,p.59S
LIU,X.L. et al,The protective effect of hepatocyte growth-promoting factor (pHGF) against hydrogen peroxide-induced acute lung injury in rats,Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan,2001年,Vol.34, No.2,p.92-102
Attorney, Agent or Firm:
Ryu Iwatani