Title:
ニコチン性アセチルコリン受容体リガンドとしてのジアザ2環式誘導体
Document Type and Number:
Japanese Patent JP4676062
Kind Code:
B2
Abstract:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.
Inventors:
Bunnell, William H
Cristina, Daniela Barrotko
Danen, Jerome F
Dirt, Michael Jay
Mayer, Michael Day
Riser, Keith Bee
Michael Shulimp
Kevin Bii
Towpence, Lithium Bee
Cristina, Daniela Barrotko
Danen, Jerome F
Dirt, Michael Jay
Mayer, Michael Day
Riser, Keith Bee
Michael Shulimp
Kevin Bii
Towpence, Lithium Bee
Application Number:
JP2000596011A
Publication Date:
April 27, 2011
Filing Date:
January 25, 2000
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07D487/08; A61K31/407; A61K31/4355; A61K31/4365; A61K31/439; A61K31/4439; A61K31/444; A61K31/4709; A61K31/497; A61K31/501; A61K31/502; A61P1/00; A61P1/04; A61P9/10; A61P15/00; A61P15/10; A61P25/00; A61P25/02; A61P25/06; A61P25/08; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; C07D401/08; C07D471/08; C07D491/048; C07D495/04; C07D519/00; A61K31/00
Domestic Patent References:
| JP2002531568A |
Foreign References:
| US5478939 | ||||
| WO1998054182A1 | ||||
| WO1998054181A1 |
Other References:
Daniela Barlocco et al.,Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling,Journal of Medicinal Chemistry,1998年,Vol.41, No.5,p.674-681
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Akio Ichiiri
Katsuma Osaki
Takamasa Soma
Makoto Ono
Akio Ichiiri
Katsuma Osaki
Takamasa Soma