Title:
アテローム性動脈硬化症の診断法
Document Type and Number:
Japanese Patent JP4680185
Kind Code:
B2
Abstract:
The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.
Inventors:
Rowe, Philip, Stewart
Application Number:
JP2006514981A
Publication Date:
May 11, 2011
Filing Date:
May 27, 2004
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION
International Classes:
A61K49/00; A61K39/395; A61K47/22; A61K47/48; A61K51/00; G01N33/50; G01N33/53; G01N33/92; A61B
Foreign References:
| WO2002087424A1 |
Other References:
Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis ,ARTHRITIS & RHEUMATISM,2002年,Vol. 46, No.7,pp 1947-1955
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation