Title:
5-HT1Fアゴニストとしての置換された2-カルボニルアミノ-6-ピペリジンアミノピリジンおよび置換された1-カルボニルアミノ-3-ピペリジンアミノベンゼン
Document Type and Number:
Japanese Patent JP4700614
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, wherein X is C(R3c)═ or N═; R1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 n-alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II provided that when R1 is C2-C6 alkyl or substituted C2-C6 alkyl, R2 is hydrogen or methyl; R3a, R3b and, when X is —C(R3c)═, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3c may be other than hydrogen; R4 is hydrogen or C1-C3 alkyl; R5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided that when R3a is other than hydrogen, R5 is hydrogen; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.
More Like This:
Inventors:
Maria-Jesus Blanco-Pillad
Michael Philip Cohen
Sandra Ann Fira
Kevin John Hazyac
Daniel Timothy Coleman
Dana Ray Benesh
Franz Victor
Yao-Chan Shu
Buy-Pin In
Diana Piat Zucker
Day Chan
Brian michael mates
Michael Philip Cohen
Sandra Ann Fira
Kevin John Hazyac
Daniel Timothy Coleman
Dana Ray Benesh
Franz Victor
Yao-Chan Shu
Buy-Pin In
Diana Piat Zucker
Day Chan
Brian michael mates
Application Number:
JP2006526084A
Publication Date:
June 15, 2011
Filing Date:
September 03, 2004
Export Citation:
Assignee:
Eli Lilly and Company
International Classes:
C07D211/58; C07D401/06; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/12; C07D409/14; A61K31/4535; A61K31/454; A61K31/4545; A61P1/02; A61P1/14; A61P3/04; A61P15/00; A61P15/10; A61P25/00; A61P25/04; A61P25/06; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P43/00
Domestic Patent References:
| JP2002536434A | ||||
| JP2001501946A |
Foreign References:
| WO2001068585A1 | ||||
| WO2003084949A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Yushiro Tsuboi
Nagatoshi Shinagawa
Kure Hidenori
Samejima Mutsumi
Masahiro Nitta
Yushiro Tsuboi
Nagatoshi Shinagawa
Kure Hidenori