Title:
改変型ビタミンK依存性ポリペプチド
Document Type and Number:
Japanese Patent JP4709395
Kind Code:
B2
Abstract:
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are described.
Inventors:
Nerces Twen, Gary, Elle.
Application Number:
JP2000615775A
Publication Date:
June 22, 2011
Filing Date:
April 28, 2000
Export Citation:
Assignee:
Regents of the University of Minnesota
International Classes:
C12N15/09; A61K38/00; A61K38/43; A61P7/02; A61P7/04; C07K14/745; C12N5/10; C12N9/64; C12N15/12; C12N15/55; C12N15/57; C12P21/02; G01N33/15; G01N33/50
Domestic Patent References:
| JP2001520042A |
Foreign References:
| WO1988010295A1 |
Other References:
FEBS Letters, (1996), Vol. 385, p. 241-243
Biochemistry, (1997), Vol. 36, p. 5120-5127
Proc. Natl. Acad. Sci. USA, (1998), Vol. 95, p. 4229-4234
ZA 9809597 南アフリカ共和国出願公開,1999年 4月23日
Biochemistry, (1997), Vol. 36, p. 5120-5127
Proc. Natl. Acad. Sci. USA, (1998), Vol. 95, p. 4229-4234
ZA 9809597 南アフリカ共和国出願公開,1999年 4月23日
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Satoshi Fujita
Natsuo Tanaka