Title:
改善された発現エレメント
Document Type and Number:
Japanese Patent JP4709743
Kind Code:
B2
Abstract:
The invention relates to improved genetic elements providing high levels of expression of operably-linked genes in a variety of tissues, In particular, fragments of unmethylated, CpG islands of less than 2kb are shown to provide enhanced transgene expression and have advantages in terms of vector construction and cloning capacity.
Inventors:
Williams, Stephen Geraint
Crohnby, Robert Lachlan
Lipinski, Kai Stefan
Irvine, Alistair Simpson
Crohnby, Robert Lachlan
Lipinski, Kai Stefan
Irvine, Alistair Simpson
Application Number:
JP2006502220A
Publication Date:
June 22, 2011
Filing Date:
February 02, 2004
Export Citation:
Assignee:
MILLIPORE CORPORATION
International Classes:
C12N15/09; A01K67/027; A61K48/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/85; C12Q1/68
Foreign References:
| WO2000005393A1 | ||||
| WO2002024930A1 |
Other References:
KOZU T,GENOMICS,米国,ACADEMIC PRESS,1995年 1月20日,V25 N2,P365-371
HUXLEY C,MOLECULAR CELL BIOLOGY,1990年 2月,V10 N2,P605-614
ANTONIOU M,GENOMICS,米国,ACADEMIC PRESS,2003年 9月,V82 N3,P269-279
HUXLEY C,MOLECULAR CELL BIOLOGY,1990年 2月,V10 N2,P605-614
ANTONIOU M,GENOMICS,米国,ACADEMIC PRESS,2003年 9月,V82 N3,P269-279
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita