Title:
スピロピペリジン化合物およびその医薬用途
Document Type and Number:
Japanese Patent JP4710606
Kind Code:
B2
Abstract:
The present invention relates to a spiro-piperidine compound represented by formula (I):
wherein R 1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s); and ring A represents a 5- to 8-membered cyclic group which may have a substituent(s), a salt thereof, an N-oxide thereof, a quaternary ammonium salt thereof or a solvate thereof, or a prodrug thereof. The compounds represented by formula (I) have chemokine antagonistic action, so that they are useful for prevention and/or treatment of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, or HIV infection.
Inventors:
Rena Nishizawa
Yoshikazu Takaoka
Hiroshi Width
Shiro Shibayama
Masaya Kokubo
Yoshikazu Takaoka
Hiroshi Width
Shiro Shibayama
Masaya Kokubo
Application Number:
JP2005505481A
Publication Date:
June 29, 2011
Filing Date:
April 16, 2004
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
A61K31/438; C07D471/10; A61K31/499; A61K31/527; A61K31/5517; A61P1/00; A61P1/04; A61P1/16; A61P3/10; A61P9/08; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P11/16; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P31/18; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D498/10
Domestic Patent References:
| JPH08512034A | 1996-12-17 | |||
| JPH0418092A | 1992-01-22 | |||
| JPS4913184A | 1974-02-05 | |||
| JPS4972332A | 1974-07-12 | |||
| JPH11512723A | 1999-11-02 | |||
| JP2002201178A | 2002-07-16 | |||
| JP2002348288A | 2002-12-04 |
Foreign References:
| WO2002074770A1 | 2002-09-26 | |||
| WO2003020721A1 | 2003-03-13 | |||
| WO2002014271A1 | 2002-02-21 | |||
| US6291469B1 | 2001-09-18 | |||
| WO2003024941A1 | 2003-03-27 | |||
| US5962462A | 1999-10-05 |
Attorney, Agent or Firm:
Kunihisa Landlord
Atsushi Hayashi
Atsushi Hayashi