Title:
生理的条件下でのウイルス粒子様構造体及びその形成方法
Document Type and Number:
Japanese Patent JP4734608
Kind Code:
B2
Abstract:
There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130 mM to 170 mM sodium chloride and 1.5 mM to 2.5 mM divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral particles, the substance to be encapsulated is included during the incubation.
Inventors:
Hiroshi Handa
Akira Nakanishi
Masaaki Kawano
Akira Nakanishi
Masaaki Kawano
Application Number:
JP2006528951A
Publication Date:
July 27, 2011
Filing Date:
June 30, 2005
Export Citation:
Assignee:
National University Corporation Tokyo Institute of Technology
International Classes:
C07K14/025; A61K35/76; A61K38/00; A61K48/00; C07K1/113; C12N7/00; C12N15/09
Domestic Patent References:
| JP2002360266A | 2002-12-17 | |||
| JP2000511773A | 2000-09-12 | |||
| JP2002500637A | 2002-01-08 |
Foreign References:
| WO1991004330A1 | 1991-04-04 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura