Title:
核因子κB誘導因子
Document Type and Number:
Japanese Patent JP4750999
Kind Code:
B2
Abstract:
The present invention is directed to nuclear factor kB (NFkB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NKkB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFkB induction in a patient, methods and compositions for lowering NFkB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treament and/or prevention of an NFkB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
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Inventors:
June Caprow
Thomas hoes
Marie Roger
Patrice Denefull
Thomas hoes
Marie Roger
Patrice Denefull
Application Number:
JP2001572589A
Publication Date:
August 17, 2011
Filing Date:
April 02, 2001
Export Citation:
Assignee:
Aventis Pharmaceuticals Incorporated
International Classes:
C12N15/09; A61K31/7088; A61K35/76; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P9/10; A61P29/00; A61P37/02; A61P43/00; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/68
Foreign References:
| WO2000012527A1 | 2000-03-09 | |||
| WO1999001541A1 | 1999-01-14 | |||
| WO1997037020A1 | 1997-10-09 | |||
| WO2000000599A2 | 2000-01-06 |
Attorney, Agent or Firm:
Junji Yuda
Chika Takagi
Kosuke Nishimura
Chika Takagi
Kosuke Nishimura