Title:
ケモカインレセプターの阻害剤として有用なビピペリジニル誘導体
Document Type and Number:
Japanese Patent JP4757802
Kind Code:
B2
Abstract:
In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
Inventors:
Miller, Michael W.
Scott, Jack Dee.
Scott, Jack Dee.
Application Number:
JP2006538391A
Publication Date:
August 24, 2011
Filing Date:
November 01, 2004
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D401/14; A61K31/445; A61K31/506; A61K31/5377; A61P1/00; A61P11/06; A61P17/06; A61P31/18; A61P37/00; A61P37/06; A61P43/00; C07D413/14
Foreign References:
| WO2002081449A1 | 2002-10-17 | |||
| US6387930B1 | 2002-05-14 | |||
| WO2002079194A1 | 2002-10-10 | |||
| WO2003020716A1 | 2003-03-13 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita