Title:
免疫したゼノマウス(XenoMouse)に由来するヒト抗体
Document Type and Number:
Japanese Patent JP4772092
Kind Code:
B2
Abstract:
Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
Inventors:
Kusher Lapaty Raju
Jacobo Bits Aya
Kraholtz sue
Brenner Daniel G.
Capon Daniel Jay.
Jacobo Bits Aya
Kraholtz sue
Brenner Daniel G.
Capon Daniel Jay.
Application Number:
JP2008231138A
Publication Date:
September 14, 2011
Filing Date:
September 09, 2008
Export Citation:
Assignee:
Amgen Fremont Ink.
International Classes:
C07K16/18; C12N15/09; A61K39/395; A61P35/00; A61P43/00; C07K16/00; C07K16/12; C07K16/22; C07K16/24; C07K16/28; C07K16/42; C12N5/10; G01N33/531; A61K38/00
Domestic Patent References:
| JP2007167070A |
Foreign References:
| WO1994002602A1 | ||||
| WO1994025585A1 |
Other References:
Nature Genetics, 1994, Vol.7, p.13-21
Nature, 1994, Vol.368, p.856-859
The Journal of Biological Chemistry, 1985, vol.260, p.315-319
The Journal of Biological Chemistry, 1984, vol.259, p.14631-14636
Current opinion in genetics & development. 1995 Jun, Vol.5, No.3, p.342-348
Nature, 1994, Vol.368, p.856-859
The Journal of Biological Chemistry, 1985, vol.260, p.315-319
The Journal of Biological Chemistry, 1984, vol.259, p.14631-14636
Current opinion in genetics & development. 1995 Jun, Vol.5, No.3, p.342-348
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita