Title:
改変型IL-4ムテイン受容体アンタゴニスト
Document Type and Number:
Japanese Patent JP4774368
Kind Code:
B2
Abstract:
This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of administration thereof for therapeutic purposes are also provided. These modified IL-4 mutein receptor antagonists, compositions and methods provide a treatment option for those individuals afflicted with a respiratory disorder such as asthma by inhibiting IL-4 and IL-13-mediated airway hyperresponsiveness and eosinophilia. More particularly, these antagonists have an increased duration of effect versus unmodified IL-4RA by virtue of a greater plasma half-life.
Inventors:
Bread clark
Rock Nearack Steve
Greve Jeffrey Michael
Yun Stephanie L.
Longfear Marinda
Wong Theresa Moe-Fan
Tomkinson Adrian
Rock Nearack Steve
Greve Jeffrey Michael
Yun Stephanie L.
Longfear Marinda
Wong Theresa Moe-Fan
Tomkinson Adrian
Application Number:
JP2006524657A
Publication Date:
September 14, 2011
Filing Date:
July 20, 2004
Export Citation:
Assignee:
Aerovance Incorporated
International Classes:
C12N15/09; A61K38/00; A61K38/17; A61P11/00; A61P11/06; A61P43/00; C07K14/54; C07K14/715; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| JP2000515016A | 2000-11-14 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi