Title:
アミド化合物およびその用途
Document Type and Number:
Japanese Patent JP4776136
Kind Code:
B2
Abstract:
The present invention relates to an amide compound of the formula wherein R<1> is a hydrogen and the like, R<2> is a hydrogen and the like, X is SO2 and the like, Y is the formula (III) and the like and a is 2, an isomer thereof or pharmaceutically acceptable salts thereof. The compound of the present invention shows a remarkable and selective Rho kinase inhibitory action, is free of problematic toxicity, shows fine oral absorption and drug kinetics (absorption, distribution, metabolism, excretion and the like of the drug), and shows superior properties (e.g., stability etc.) as a compound. Accordingly, it can be used as a therapeutic drug for various diseases in which Rho kinase is involved.
Inventors:
Shinichi Takanashi
Yoichiro Naito
Hiroshi Tanaka
Uehata Masayoshi
Hiroshiro Katayama
Yoichiro Naito
Hiroshi Tanaka
Uehata Masayoshi
Hiroshiro Katayama
Application Number:
JP2001567702A
Publication Date:
September 21, 2011
Filing Date:
March 16, 2001
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
International Classes:
C07D213/75; A61K31/437; A61K31/4409; A61K31/4433; A61K31/4436; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P15/04; A61P15/06; A61P15/10; A61P15/18; A61P19/00; A61P19/08; A61P19/10; A61P25/00; A61P25/04; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P43/00; C07D405/12; C07D409/12; C07D471/04; C07D487/04
Domestic Patent References:
| JP2000063274A | 2000-02-29 | |||
| JPH11130751A | 1999-05-18 | |||
| JP2000063274A | 2000-02-29 | |||
| JPH11130751A | 1999-05-18 |
Foreign References:
| WO1998006433A1 | 1998-02-19 | |||
| WO1998006433A1 | 1998-02-19 |
Other References:
JPN6010073923, Ａｍ． Ｊ． Ｐｈｙｓｉｏｌ． Ｃｅｌｌ Ｐｈｙｓｉｏｌ．, 200001, Ｖｏｌ．２７８, Ｃ５７−Ｃ６５
Attorney, Agent or Firm:
Takashima Ichi