Title:
移植材料及びその製造方法
Document Type and Number:
Japanese Patent JP4777568
Kind Code:
B2
Abstract:
The present invention provides implant materials capable of imparting desired mechanical properties and enhancing bone tissue repair speed and biocompatibility, and method for fabricating the implant materials. The implant material, which includes an artificial and bioinert material, is obtained by the steps of adhering at least one kind of cells selected from osteoblasts and osteoprogenitor cells to the surface of the artificial and bioinert material to be implanted in a living body as a replacement for bone tissue, and coating the artificial material with bone matrix produced by the adhered cells. The artificial material includes not only a bioinert material but also a bioinert material having a surface coated with a bioactive substrate. The implant material is produced by culturing mesenchymal stem cells obtained from a living body to differentiate to at least one kind of cells selected from osteoblasts and osteoprogenitor cells, culturing the differentiated cells together with the artificial material so that the differentiated cells are adhered to the surface of the artificial material, and coating the surface of the artificial material with bone matrix produced by the differentiated cells.
Inventors:
Beginning of Ogushi
Application Number:
JP2001536213A
Publication Date:
September 21, 2011
Filing Date:
November 09, 2000
Export Citation:
Assignee:
Japan Tissue Engineering Co., Ltd.
Beginning of Ogushi
Kyocera Corporation
Beginning of Ogushi
Kyocera Corporation
International Classes:
A61L27/00; A61L27/36; A61L27/38
Domestic Patent References:
| JPH08112341A | 1996-05-07 |
Foreign References:
| WO1997040137A1 | 1997-10-30 |
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda