Title:
塩素イオン輸送の調節における活性に関する化合物のスクリーニング
Document Type and Number:
Japanese Patent JP4791551
Kind Code:
B2
Abstract:
A method for screening a test compound for activity in modulating the activity of the chloride channel ClC-7 either directly or by modulating the subcellular localization of Ostm1 comprises determining whether test compound inhibits the binding of Ostm1 to ClC-7. Compounds active in the screen are candidates for use in treating bone resorption conditions such as Osteoporosis by modulating the activity of osteoclasts.
Inventors:
Lange, Philip F
Hoorman, Jens See
Yen Chu, Thomas Jay
Hoorman, Jens See
Yen Chu, Thomas Jay
Application Number:
JP2008546411A
Publication Date:
October 12, 2011
Filing Date:
December 18, 2006
Export Citation:
Assignee:
Farmos Bioscience Actieslsk
International Classes:
G01N33/50; C12Q1/02; G01N33/15; A61K45/00; A61P19/08; A61P19/10
Domestic Patent References:
| JP2004522441A | ||||
| JP2004531227A | ||||
| JP2008541781A |
Foreign References:
| US20030215787 | ||||
| US20040009915 | ||||
| US20040219511 |
Other References:
CLEIREN E,HUMAN MOLECULAR GENETICS,英国,OXFORD UNIVERSITY PRESS,2001年,V10 N25,P2861-2867
QUARELLO PAOLA,JOURNAL OF BONE AND MINERAL RESEARCH,AMERICAN SOCIETY FOR BONE AND NINERAL RESEARCH,2004年 7月,V19 N7,P1194-1199
RAMIREZ ALFREDO,HUMAN MUTATION,2004年 5月,V23 N5,P471-476
KORNAK U,CELL,米国,CELL PRESS,2001年 1月26日,V104,P205-215
QUARELLO PAOLA,JOURNAL OF BONE AND MINERAL RESEARCH,AMERICAN SOCIETY FOR BONE AND NINERAL RESEARCH,2004年 7月,V19 N7,P1194-1199
RAMIREZ ALFREDO,HUMAN MUTATION,2004年 5月,V23 N5,P471-476
KORNAK U,CELL,米国,CELL PRESS,2001年 1月26日,V104,P205-215
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto