Title:
アムホテリシンB構造化エマルション
Document Type and Number:
Japanese Patent JP4804702
Kind Code:
B2
Abstract:
Parenteral compositions of oil-coated-Amphotericin B in structured-emulsion form, having LD50 of at least 400 mg/kg in mice and process for making the same have been described. The process essentially requires dispersing Amphotericin B in oily vehicle and dispersing emulsifier in the aqueous phase. The process of present invention is simple, cost effective and gives a stable product suitable for parenteral administration. Amphotericin B emulsion compositions prepared by the process of the present invention may be administered to human beings and animals for the treatment of fungal infections, with substantially equivalent or greater efficacy and low drug toxicity as compared to the conventional composition containing Amphotericin B and sodium desoxycholate.
Inventors:
Pies Ricans Annapa
Revanker San Gita Haneul Mesh
Kocharekar Silpa Sadakar
Revanker San Gita Haneul Mesh
Kocharekar Silpa Sadakar
Application Number:
JP2002503255A
Publication Date:
November 02, 2011
Filing Date:
June 19, 2001
Export Citation:
Assignee:
Bucharat Serms and Vaxins Limited
International Classes:
A61K31/7048; C07H17/08; A61K9/107; A61K47/10; A61K47/20; A61K47/24; A61K47/26; A61K47/44; A61K47/46; A61P31/10
Domestic Patent References:
| JP61268625A | ||||
| JP5500062A | ||||
| JP2290809A | ||||
| JP11060491A | ||||
| JP4173736A | ||||
| JP10511382A |
Foreign References:
| EP0296845A1 |
Other References:
Antimicrobial Agents and Chemotherapy,1998年,Vol.42,No.4,pages 762-766
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda