Title:
アスパルチルプロテアーゼのインヒビター
Document Type and Number:
Japanese Patent JP4814427
Kind Code:
B2
Abstract:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
Inventors:
Hale, Michael Earl.
Baker, Christopher Tee.
Starmers, Timothy A.
Sheryl, Ronald G.
Spartenstein, Andrew
Far Fine, Eric S.
Martés, Francois
Andrews, Clarence Webster The Third
Miller, John F.
Samano, Vicent
Baker, Christopher Tee.
Starmers, Timothy A.
Sheryl, Ronald G.
Spartenstein, Andrew
Far Fine, Eric S.
Martés, Francois
Andrews, Clarence Webster The Third
Miller, John F.
Samano, Vicent
Application Number:
JP2000598472A
Publication Date:
November 16, 2011
Filing Date:
February 09, 2000
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07C311/29; C07D317/28; A61K9/20; A61K9/48; A61K31/27; A61K31/275; A61K31/34; A61K31/341; A61K31/357; A61K31/36; A61K31/5377; A61K31/662; A61P31/14; A61P31/18; A61P43/00; C07B53/00; C07C271/20; C07C271/22; C07C311/19; C07C311/42; C07C311/46; C07C317/18; C07D307/20; C07D317/62; C07D319/06; C07D409/12; C07D493/04; C07F9/6561
Domestic Patent References:
| JP11500105A | ||||
| JP10509739A | ||||
| JP8501299A | ||||
| JP8501288A | ||||
| JP2000515488A | ||||
| JP11504628A | ||||
| JP8500825A |
Foreign References:
| WO1994010136A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto