Title:
肝疾患の診断及び治療
Document Type and Number:
Japanese Patent JP4817494
Kind Code:
B2
Abstract:
The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM binding partner or ligand. These compositions are useful in treating diseases or disorders involving alpha 4 beta 7/MAdCAM blockade, as well as inhibiting a primary event in the inflammatory response such as blocking interactions between intercellular adhesion molecules and their ligands. Disorders treatable using the methods disclosed herein include infections, especially viral infections, iatrogenic disorders, cholestatic disorders, hereditary disorders, sarcoidosis, organ transplant, and the like. The diagnostic methods of the invention can be employed to detect the presence of a disorder or to monitor the course of therapy used to treat the disorder.
More Like This:
| WO/2002/026996 | REGULATION OF HUMAN PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C-LIKE ENZYME |
| WO/2002/068466 | HYPOXIA-REGULATED GENES |
| WO/2002/022156 | TOPICAL FORMULATIONS FOR DELIVERY OF INTERLEUKIN-11 |
Inventors:
Phone, shaman
Gillan, Kenneth, J.
Gillan, Kenneth, J.
Application Number:
JP2000548375A
Publication Date:
November 16, 2011
Filing Date:
May 12, 1999
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
A61K38/00; G01N33/576; A61K39/395; A61K45/00; A61P1/16; C07K14/705; C07K16/28; C12N5/10; C12N5/20; C12P21/08; G01N33/577; G01N33/68; C12R1/91
Foreign References:
| WO1997025351A2 | 1997-07-17 | |||
| WO1996024673A1 | 1996-08-15 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori