Title:
STAT3活性化幹細胞
Document Type and Number:
Japanese Patent JP4834291
Kind Code:
B2
Abstract:
Stem cells modified to express activated form of STAT3 by genetic modification or protein delivery, and stem cells co-cultured with cells expressing activated form of STAT3 exhibit increased ex-vivo expansion and enhanced in-vivo regeneration accompanied by net increase in stem cell self-renewal as compared to control group.
Inventors:
Oh, Il-Huang
Application Number:
JP2003568067A
Publication Date:
December 14, 2011
Filing Date:
February 17, 2003
Export Citation:
Assignee:
Industry-Academic Co-Operation Foundation, The Catholic University of Korea
International Classes:
C12N5/10; C12N15/09; A61K35/12; A61K35/14; A61K35/28; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07K14/47; C12N5/02; C12N5/0789
Other References:
EMBO J., vol.18(15), pp.4261-4269(1999)
Genes and Develop., vol.12, pp.2048-2060(1998)
Proc.Natl.Acad.Sci.USA., vol.96, pp.2846-2851(1999)
Cell, vol.98, pp.295-303(1999)
Genes and Develop., vol.12, pp.2048-2060(1998)
Proc.Natl.Acad.Sci.USA., vol.96, pp.2846-2851(1999)
Cell, vol.98, pp.295-303(1999)
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Yuriko Shinobu
Takuya Osugi