Title:
プロテインキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP4845736
Kind Code:
B2
Abstract:
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure: including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from: and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
Inventors:
Harley, Lawrence, H.
Mahadevan, Darka
Han, Hyeon
Bears, David, Jay.
Vankayala Pachi, Hali Prasad
Bashyam, Sri Devi
Munoz, Reuben, M.
Warner, Stephen, Elle.
Dela Claus, Kimiko
Van Hoff, Daniel, Dee.
Grand, Collie, Elle.
Mahadevan, Darka
Han, Hyeon
Bears, David, Jay.
Vankayala Pachi, Hali Prasad
Bashyam, Sri Devi
Munoz, Reuben, M.
Warner, Stephen, Elle.
Dela Claus, Kimiko
Van Hoff, Daniel, Dee.
Grand, Collie, Elle.
Application Number:
JP2006535644A
Publication Date:
December 28, 2011
Filing Date:
October 14, 2004
Export Citation:
Assignee:
ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA
International Classes:
C07D487/04; A61K31/517; A61K31/519; A61K31/5377; A61P35/00; A61P43/00; C07D239/94; C07D405/12; C07D405/14; C07D487/02; C07D487/14; C07D491/04; C07D491/048; C07D495/04; C07D495/14
Domestic Patent References:
| JPH10175977A | 1998-06-30 |
Foreign References:
| WO2003051884A1 | 2003-06-26 |
Attorney, Agent or Firm:
Tomimasa Konishi
Tomoko Nakamura
Mikiharu Hagino
Tomoko Nakamura
Mikiharu Hagino