Title:
ヒドロモルフィノン及びヒドロコデイノン組成物、並びに、それらの合成方法
Document Type and Number:
Japanese Patent JP4886953
Kind Code:
B2
Abstract:
A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial absence of hydrogen gas. Also disclosed is a method of forming a pharmaceutical composition comprising a hydromorphone salt, 8-hydroxy hydromorphone and dihydromorphone by heating an aqueous mixture of said salt, 8-hydroxy hydromorphone and dihydromorphone for a time sufficient to reduce the concentration of 8-hydroxy hydromorphone to less than about 1.0%. The methods are useful for preparing hydromorphone or hydrocodone compositions having novel impurity profiles.
Inventors:
Herculerode, William H
Robert Gault
Sundayson, mark day
Robert Gault
Sundayson, mark day
Application Number:
JP2001537321A
Publication Date:
February 29, 2012
Filing Date:
November 09, 2000
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07D489/02; A61K31/485; A61P25/04; B01J23/42; B01J23/44; C07B61/00
Foreign References:
| US2654756A | 1953-10-06 | |||
| GB285404A | ||||
| WO1998005667A1 | 1998-02-12 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Katsuma Osaki
Takamasa Soma
Mitsuru Inoue
Akio Ichiiri
Katsuma Osaki
Takamasa Soma