Title:
ネプラノシンAの新規製造方法及び中間体
Document Type and Number:
Japanese Patent JP4899022
Kind Code:
B2
Abstract:
Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.02,6]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.02,6]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.
Inventors:
Naoyuki Yoshida
Kunio Ogasawara
Kunio Ogasawara
Application Number:
JP2008107462A
Publication Date:
March 21, 2012
Filing Date:
April 17, 2008
Export Citation:
Assignee:
JNC Corporation
International Classes:
C07D473/34; C07C35/37; C07C49/643; C07C69/00; C07D303/32; C07D307/77; C07D317/70; C07D473/00; C07D493/08; C07F7/18; C07F7/08; C07F7/10
Domestic Patent References:
| JP9502986A | ||||
| JP5092974A |
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