Title:
キナーゼインヒビターとして有用な、フェニル置換ピリミジン化合物
Document Type and Number:
Japanese Patent JP4906738
Kind Code:
B2
Abstract:
Compounds having the formula (I), and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein: two of X1, X2, and X3 are N, and the remaining one of X1, X2, and X3 is —CR1; R1 is hydrogen or —CN; and N, G, Z, R2, R3, R4, R5, and R6 are described in the specification. Also disclosed are pharmaceutical compositions containing compounds of formula (I), and methods of treating conditions associated with the activity of p38 kinase and/or conditions associated with the activity of LIM kinase.
Inventors:
Steven T. Robleski
Lynn Shukun
Katerina Lefferis
Riki He
Steven P. Sights
Thailand-Ann Lin
Wayne Baccaro
Lynn Shukun
Katerina Lefferis
Riki He
Steven P. Sights
Thailand-Ann Lin
Wayne Baccaro
Application Number:
JP2007554206A
Publication Date:
March 28, 2012
Filing Date:
February 02, 2006
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D417/04; C07D417/14; A61K31/506; A61K31/5377; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2003528872A | ||||
| JP2003527376A | ||||
| JP2001199982A |
Foreign References:
| WO2004080979A1 | ||||
| WO1996032384A1 | ||||
| WO2004096797A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Masahiro Nitta
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Masahiro Nitta