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Title:
嚢胞性線維症膜コンダクタンス制御因子蛋白質阻害薬およびその使用方法
Document Type and Number:
Japanese Patent JP4977319
Kind Code:
B2
Abstract:
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions and pharmaceutical preparations of the invention may comprise one or more thiazolidinone compounds, and may additionally comprise one or more pharmaceutically acceptable carriers, excipients and/or adjuvants. The methods of the invention comprise, in certain embodiments, administering to a patient suffering from a CFTR-mediated disease or condition, an efficacious amount of a thiazolidinone compound. In other embodiments the invention provides methods of inhibiting CFTR that comprise contacting cells in a subject with an effective amount of a thiazolidinone compound. In addition, the invention features a non-human animal model of CFTR-mediated disease which model is produced by administration of a thiazolidinone compound to a non-human animal in an amount sufficient to inhibit CFTR.

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Inventors:
Bergmann Alan
Mar Ton Hoi
Application Number:
JP2004540305A
Publication Date:
July 18, 2012
Filing Date:
September 30, 2003
Export Citation:
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Assignee:
The Regents of The University of California
International Classes:
A61K31/549; A61K31/4166; A61P1/04; A61P1/12; A61P31/04; A61P31/12; A61P31/18; A61P33/00; A61P39/02; A61P43/00; C07D277/20; C07D277/36
Domestic Patent References:
JP2000503679A
JP4279573A
JP2002523371A
JP2004517085A
Foreign References:
WO2002004167A1
Other References:
S. P. Gupta et al.,Synthesis and Fungitoxicity of Some 5-Substituted 3-Polynitrophenyl Rhodamines,J. Indian Chem. Soc.,1978年,p.483-485
Roman, O. M. et al.,Synthesis and antiinflammatory activity of 3-aryl-5-arylidene-2-thioxothiazolidine-4-ones,Farmatsevtichnii Zhurnal (Kiev),2002年,(3),p.56-59
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi



 
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