Title:
自己免疫障害後の中枢神経系の神経再生に用いるEGF/GHRP-6の組合せ
Document Type and Number:
Japanese Patent JP5001180
Kind Code:
B2
Abstract:
The present invention is directed to stimulate the neuroregeneration of the central nervous system due to autoimmune damage. In particular the pharmaceutical combination that comprise therapeutically effective concentrations of the Epidermal Growth Factor and the Growth Hormone Releasing Peptide-6, is administrated to a subject that suffers from symptoms of Multiple Sclerosis and Optic Neuromyelitis and corrects the demyelination caused by autoreactive cells in central nervous system.
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Inventors:
Garcia del Barco Herrera, Diana
Gillen Nieto, Herald, Enrique
Berlanga Acosta, Jorge Amador
Freire Almeida, Freya, De Los Milagros
Siberian Bella, Danai
Penton Arias, Eduardo
Gillen Nieto, Herald, Enrique
Berlanga Acosta, Jorge Amador
Freire Almeida, Freya, De Los Milagros
Siberian Bella, Danai
Penton Arias, Eduardo
Application Number:
JP2007557312A
Publication Date:
August 15, 2012
Filing Date:
February 24, 2006
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
A61K38/08; A61K38/22; A61P25/00
Domestic Patent References:
| JP2005500077A |
Foreign References:
| WO2005017132A1 |
Other References:
FRAGO,L.M. et al,Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection,Endocrinology,2002年,Vol.143, No.10,p.4113-22
PLATA-SALAMAN,C.R.,Epidermal growth factor and the nervous system,Peptides,1991年,Vol.12, No.3,p.653-63
KNAPP,P.E. et al,Epidermal growth factor promotes oligodendrocyte process formation and regrowth after injury,Exp Cell Res,2004年,Vol.296, No.2,p.135-44
ARSENIJEVIC,Y. et al,Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neuronal precursors: distinct actions from those of brain-derived neurotrophic factor,J Neurosci,1998年,Vol.18, No.6,p.2118-28
KUHN,H.G. et al,Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain,J Neurosci,1997年,Vol.17, No.15,p.5820-9
RAINETEAU,O. et al,Neurogenesis in hippocampal slice cultures,Mol Cell Neurosci,2004年,Vol.26, No.2,p.241-50
SCHNEIDER,H.J. et al,Central effects of the somatotropic system,Eur J Endocrinol,2003年,Vol.149, No.5,p.377-92
HARVEY,S. et al,Neural growth hormone: an update,J Mol Neurosci,2003年,Vol.20, No.1,p.1-14
田平武,サイトカインの最新動向 神経系とサイトカイン,週刊医学のあゆみ,1995年,Vol.174, No.14,1114-8
三浦正幸,多発性硬化症とオリゴデンドロサイト細胞死:カスパーゼの関与について,炎症と免疫,2002年,Vol.10, No.5,522-8
PLATA-SALAMAN,C.R.,Epidermal growth factor and the nervous system,Peptides,1991年,Vol.12, No.3,p.653-63
KNAPP,P.E. et al,Epidermal growth factor promotes oligodendrocyte process formation and regrowth after injury,Exp Cell Res,2004年,Vol.296, No.2,p.135-44
ARSENIJEVIC,Y. et al,Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neuronal precursors: distinct actions from those of brain-derived neurotrophic factor,J Neurosci,1998年,Vol.18, No.6,p.2118-28
KUHN,H.G. et al,Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain,J Neurosci,1997年,Vol.17, No.15,p.5820-9
RAINETEAU,O. et al,Neurogenesis in hippocampal slice cultures,Mol Cell Neurosci,2004年,Vol.26, No.2,p.241-50
SCHNEIDER,H.J. et al,Central effects of the somatotropic system,Eur J Endocrinol,2003年,Vol.149, No.5,p.377-92
HARVEY,S. et al,Neural growth hormone: an update,J Mol Neurosci,2003年,Vol.20, No.1,p.1-14
田平武,サイトカインの最新動向 神経系とサイトカイン,週刊医学のあゆみ,1995年,Vol.174, No.14,1114-8
三浦正幸,多発性硬化症とオリゴデンドロサイト細胞死:カスパーゼの関与について,炎症と免疫,2002年,Vol.10, No.5,522-8
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio