Title:
タンパク質キナーゼインヒビターとして有用なラクタム化合物
Document Type and Number:
Japanese Patent JP5002460
Kind Code:
B2
Abstract:
The present invention provides novel compounds of formula (I)
or a pharmaceutically acceptable salt thereof;
wherein:
A, R a , R b , R c , R d , G 1 , Y 1 and Y 2 have the meanings as given in the claims
useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
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Inventors:
Blackburn, christopher
Claiborne, Christopher F.
Charis, Courtney A.
Dales, Natalie A.
Patane, Michael A.
Sterling, matthew
Stradella, Omar Gee.
Weatherhead, Gabriel S.
Claiborne, Christopher F.
Charis, Courtney A.
Dales, Natalie A.
Patane, Michael A.
Sterling, matthew
Stradella, Omar Gee.
Weatherhead, Gabriel S.
Application Number:
JP2007534851A
Publication Date:
August 15, 2012
Filing Date:
October 03, 2005
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
International Classes:
C07D471/14; A61K31/55; A61K45/00; A61P35/00; A61P43/00; C07D487/04
Domestic Patent References:
| JP2001507349A |
Foreign References:
| US20030083327 |
Other References:
LEOST,M. et al,Paullones are potent inhibitors of glycogen synthase kinase-3β and cyclin-dependent kinase 5/p25,European Journal of Biochemistry,2000年,Vol.267, No.19,p.5983-5994
WOSIKOWSKI,K. et al,Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns,Journal of the National Cancer Institute,1997年,Vol.89, No.20,p.1505-1515
WOSIKOWSKI,K. et al,Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns,Journal of the National Cancer Institute,1997年,Vol.89, No.20,p.1505-1515
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita