Title:
スフィンゴミエリン合成酵素SMS2の生理機能を応用したメタボリックシンドローム改善,又は改善薬のスクリーニング方法
Document Type and Number:
Japanese Patent JP5013561
Kind Code:
B2
Abstract:
Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.
Inventors:
Susumu Mitsutake
Yasuyuki Igarashi
Kota Zama
Tetsuya Yoshida
Kaichi Tanaka
Hiroshi Takemoto
Yasuyuki Igarashi
Kota Zama
Tetsuya Yoshida
Kaichi Tanaka
Hiroshi Takemoto
Application Number:
JP2011532908A
Publication Date:
August 29, 2012
Filing Date:
September 22, 2010
Export Citation:
Assignee:
National University Corporation Hokkaido University
Shionogi Pharmaceutical Co., Ltd.
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C12Q1/48; C12N5/10; C12N15/09
Other References:
J. Biol. Chem.,2004年,vol.279, no.18,p.18688-18693
細胞,2009年 5月20日,vol.41, no.5,p.178-181
厚生労働省がん研究助成金による研究報告集,2008年,vol.2007,p.264-268
EMBO J.,2004年,vol.23, no.1,p.33-44
細胞,2009年 5月20日,vol.41, no.5,p.178-181
厚生労働省がん研究助成金による研究報告集,2008年,vol.2007,p.264-268
EMBO J.,2004年,vol.23, no.1,p.33-44
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita