Title:
改良免疫毒素を用いた癌治療法
Document Type and Number:
Japanese Patent JP5014157
Kind Code:
B2
Abstract:
The present invention provides a modified toxin having an ETA moiety that has the furin site replaced with a cancer-associated protease site. The present invention also provides modified immunotoxins having a ligand that binds to a cancer cell attached to an ETA moiety that has the furin site replaced with a cancer-associated protease site. Also provided are a method of inhibiting or destroying mammalian cancer cells using the immunotoxins of the invention and pharmaceutical compositions for treating human cancer.
Inventors:
Tsangmeister-Witke Uwe
Di Paolo Claudio
Di Paolo Claudio
Application Number:
JP2007555528A
Publication Date:
August 29, 2012
Filing Date:
February 16, 2006
Export Citation:
Assignee:
University of Zurich
International Classes:
A61K38/00; A61K39/395; A61P35/00; A61P35/02; C07K14/21
Domestic Patent References:
| JP2001504334A |
Foreign References:
| WO2004096271A1 |
Other References:
勝田省吾,プラークの脆弱化とマトリックスメタロプロテアーゼ,THE JOURNAL OF JAPANESE COLLEGE OF ANGIOLOGY,No. 43, No. 11,p. 699-705
Shihui Liu,CANCER RESEARCH,2000年,V60,P6061-6067
FRANKEL ARTHUR E,PROTEIN AND PEPTIDE LETTERS,2002年 2月,V9 N1,P1-14
Shihui Liu,CANCER RESEARCH,2000年,V60,P6061-6067
FRANKEL ARTHUR E,PROTEIN AND PEPTIDE LETTERS,2002年 2月,V9 N1,P1-14
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi