Title:
5-フェノキシアルコキシソラーレンおよび電位開口型Kv1.3カリウムチャネルの選択的阻害方法
Document Type and Number:
Japanese Patent JP5087401
Kind Code:
B2
Abstract:
Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).
Inventors:
Wolf, Haike
Sankara Narayanan, Anan Sakrishnan
Henssel, Wolfram
Schmidz, Alexander
Schmidt-Lassen, Christina
Sankara Narayanan, Anan Sakrishnan
Henssel, Wolfram
Schmidz, Alexander
Schmidt-Lassen, Christina
Application Number:
JP2007534874A
Publication Date:
December 05, 2012
Filing Date:
October 04, 2005
Export Citation:
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
International Classes:
A61K31/37; A61K31/428; A61K31/433; A61K31/4433; A61K31/506; A61P37/06; C07D493/04
Other References:
ABEGAZ,B.M. et al,Prenylated flavonoids, monoterpenoid furanocoumarins and other constituents from the twigs of Dorstenia elliptica (Moraceae),Phytochemistry(Elsevier),2004年 1月,Vol.65, No.2,pp.221-226
GIMENEZ-ARNAU,E. et al,Synthesis and photoreaction of α-methylene-γ-butyrolactone- psoralen heterodimers,Photochemistry and Photobiology,1997年,Vol.65, No.2,pp.316-322
DECOUT,J.L. et al,Reversed-phase high-performance liquid chromatography, a tool for the study of bichromophoric systems including polymethylenic linking bridges,Journal of Chromatography,1989年,Vol.481,pp.461-4
VENNEKAMP,J. et al,Kv1.3-blocking 5-phenylalkoxypsoralens: A new class of immunomodulators,Molecular Pharmacology,2004年 6月,Vol.65, No.6,pp.1364-1374
WERMUTH,PRACTICE OF MEDICINAL CHEMISTRY,1996年,P203-237
GIMENEZ-ARNAU,E. et al,Synthesis and photoreaction of α-methylene-γ-butyrolactone- psoralen heterodimers,Photochemistry and Photobiology,1997年,Vol.65, No.2,pp.316-322
DECOUT,J.L. et al,Reversed-phase high-performance liquid chromatography, a tool for the study of bichromophoric systems including polymethylenic linking bridges,Journal of Chromatography,1989年,Vol.481,pp.461-4
VENNEKAMP,J. et al,Kv1.3-blocking 5-phenylalkoxypsoralens: A new class of immunomodulators,Molecular Pharmacology,2004年 6月,Vol.65, No.6,pp.1364-1374
WERMUTH,PRACTICE OF MEDICINAL CHEMISTRY,1996年,P203-237
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda