Title:
Yersiniapestisの免疫療法におけるフラジェリンの使用
Document Type and Number:
Japanese Patent JP5094407
Kind Code:
B2
Abstract:
The invention provides a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. Also provided are compositions comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention also discloses methods of making a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against Yersinia pestis.
Inventors:
Mizell, Stephen Bee
Anna Nicole, Honko
Anna Nicole, Honko
Application Number:
JP2007547004A
Publication Date:
December 12, 2012
Filing Date:
December 16, 2005
Export Citation:
Assignee:
Wake Forest University Health Sciences
International Classes:
C12N15/09; A61K39/00; A61K39/02; A61P31/04; C07K14/195; C07K14/255; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| JP11501654A | ||||
| JP4502402A |
Foreign References:
| WO2004022092A1 |
Other References:
Infection and Immunity, 2004年5月, 第72巻, 2810-2816ページ
TRENDS in Microbiology, 2004年11月, 第12巻, 509-517ページ
Nature Immunology, 2003年, 第4巻, 1247-1253ページ
Clinical and Vaccine Immunology, 2009年, 第16巻, 21-28ページ
The Journal of Immunology, 2001年, 第167巻, 7009-7016ページ
TRENDS in Microbiology, 2004年11月, 第12巻, 509-517ページ
Nature Immunology, 2003年, 第4巻, 1247-1253ページ
Clinical and Vaccine Immunology, 2009年, 第16巻, 21-28ページ
The Journal of Immunology, 2001年, 第167巻, 7009-7016ページ
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura