Title:
分子治療用生分解性リンカー
Document Type and Number:
Japanese Patent JP5107716
Kind Code:
B2
Abstract:
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.
Inventors:
Alferiev, Ivan
Levy, Robert Jay.
Fishvine, ilia
Levy, Robert Jay.
Fishvine, ilia
Application Number:
JP2007540091A
Publication Date:
December 26, 2012
Filing Date:
November 04, 2005
Export Citation:
Assignee:
The Children's Hospital of Philadelphia
International Classes:
A61K47/48; A61K35/76; A61K38/00; A61K47/02; A61K47/04; A61K47/30; A61K48/00
Foreign References:
| US5648506 | ||||
| US5827819 | ||||
| WO2004022099A1 | ||||
| US6273913 | ||||
| WO2004045578A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaru Nakajima