Title:
テンプレート固定ペプチド模倣薬
Document Type and Number:
Japanese Patent JP5140686
Kind Code:
B2
Abstract:
The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity.
Inventors:
Demarco, Stephen, Jay.
Mookaji, Reshmi
Moers, Kerstin
Robinson, John, Anthony
Henze, Hiko
Romagnori, Barbara
Daniel Obrecht
Gomberto, frank
Rudin, Christian
Brigi Broad, Yang, Wim
Mookaji, Reshmi
Moers, Kerstin
Robinson, John, Anthony
Henze, Hiko
Romagnori, Barbara
Daniel Obrecht
Gomberto, frank
Rudin, Christian
Brigi Broad, Yang, Wim
Application Number:
JP2009551913A
Publication Date:
February 06, 2013
Filing Date:
February 28, 2007
Export Citation:
Assignee:
Porphyr limited
Unibelgitate Zurich
Unibelgitate Zurich
International Classes:
C07K7/56; A61K38/00; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P37/06; A61P43/00; C07K1/04; C07K1/06
Foreign References:
| WO2004096840A1 | ||||
| WO2002070547A1 | ||||
| WO2001016161A1 |
Other References:
DEMARCO SJ,BIOORGANIC & MEDICINAL CHEMISTRY,2006年12月15日,V14 N24,P8396-8404
TAMAMURA HIROKAZU,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,2001年 7月23日,V11 N14,P1897-1902
TAMAMURA HIROKAZU,CURRENT HIV RESEARCH,NL,BENTHAM SCIENCE PUBLISHERS,2005年10月,V3 N4,P289-301
TAMAMURA HIROKAZU,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,2001年 7月23日,V11 N14,P1897-1902
TAMAMURA HIROKAZU,CURRENT HIV RESEARCH,NL,BENTHAM SCIENCE PUBLISHERS,2005年10月,V3 N4,P289-301
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai