薬物依存症の予防および/または治療剤

Title:

薬物依存症の予防および/または治療剤

Document Type and Number:

Japanese Patent JP5188066

Kind Code:

B2

Abstract:

A preventive and/or therapeutic agent for drug dependence which contains as an active ingredient either a compound having antagonistic activity against an adenosine A_2A receptor, such as a xanthine derivative represented by, e.g., the formula (I) (wherein R¹, R², and R³ are the same or different and each represents hydrogen, lower alkyl, lower alkenyl, or lower alkynyl; R⁴ represents cycloalkyl, -(CH₂)_n-R⁵, or the formula (II); and X¹ and X² are the same or different and each represents oxygen or sulfur) or a pharmacologically acceptable salt of the compound.

Inventors:

Junya Kase
Kurokawa Masako
Shizuo Shiozaki
Naoki Senoo

Application Number:

JP2006546639A

Publication Date:

April 24, 2013

Filing Date:

December 02, 2005

Export Citation:

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Assignee:

Kyowa Hakko Kirin Co., Ltd.

International Classes:

A61K31/522; A61P25/32; A61P43/00; C07D473/06; A61P25/30; C07D473/12

Domestic Patent References:

JPH06211856A

1994-08-02

Foreign References:

EP0431758A2	1991-06-12
EP0431758A2	1991-06-12

Other References:

JPN7012000627; ＧＡＴＣＨ，Ｍ．Ｂ．　ｅｔ　ａｌ．: 'Ｔｈｅ　ｅｆｆｅｃｔｓ　ｏｆ　ａｄｅｎｏｓｉｎｅ　ｌｉｇａｎｄｓ　Ｒ-ＰＩＡ　ａｎｄ　ＣＰＴ　ｏｎ　ｅｔｈａｎｏｌ　ｗｉｔｈｄｒａｗａｌ' ＡｌｃｏｈｏｌＶｏｌ．１９，　Ｎｏ．１, 1999, ｐ．９-１４
JPN6012008819; ＥＬ　ＹＡＣＯＵＢＩ，Ｍ．　ｅｔ　ａｌ．: 'Ａｂｓｅｎｃｅ　ｏｆ　ｔｈｅ　ａｄｅｎｏｓｉｎｅ　Ａ（２Ａ）　ｒｅｃｅｐｔｏｒ　ｏｒ　ｉｔｓ　ｃｈｒｏｎｉｃ　ｂｌｏｃｋａｄｅ　ｄｅｃｒｅａｓｅ　ｅｔｈａｎｏｌ　ｗｉｔｈｄｒａｗａｌ-ｉｎｄｕｃｅｄ' ＮｅｕｒｏｐｈａｒｍａｃｏｌｏｇｙＶｏｌ．４０，　Ｎｏ．３, 2001, ｐ．４２４-４３２
JPN6011019761; Ｓｏｃｉｅｔｙ　ｆｏｒ　Ｎｅｕｒｏｓｃｉｅｎｃｅ［ｏｎｌｉｎｅ］ , 2003, Ｎｏ．８５２．３
JPN6012008816; ＪＡＣＯＢＳＯＮ，Ｋ．Ａ．　ｅｔ　ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ-ａｃｔｉｖｉｔｙ　ｒｅｌａｔｉｏｎｓｈｉｐｓ　ｏｆ　８-ｓｔｙｒｙｌｘａｎｔｈｉｎｅｓ　ａｓ　Ａ２-ｓｅｌｅｃｔｉｖｅ　ａｄｅｎｏｓｉｎｅ　ａｎｔａｇｏｎｉｓｔｓ' Ｊ．Ｍｅｄ．Ｃｈｅｍ．Ｖｏｌ．３６，　Ｎｏ．１０, 1993, ｐ．１３３３-１３４２

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