ヒトグルココルチコイド受容体遺伝子座の修飾のための方法および組成物

Title:

ヒトグルココルチコイド受容体遺伝子座の修飾のための方法および組成物

Document Type and Number:

Japanese Patent JP5188504

Kind Code:

B2

Abstract:

Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

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Inventors:

Like, Andreas
Jensen, michael
Holmes, Michael Sea.
Gregory, Philip Dee.
And dale

Application Number:

JP2009536330A

Publication Date:

April 24, 2013

Filing Date:

November 13, 2007

Export Citation:

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Assignee:

Sangammo Biosciences, Inc.

International Classes:

C07K19/00; A61K31/573; A61P9/12; A61P11/06; A61P29/00; A61P37/06; C12N15/09

Other References:

Nature,2005年,Vol.435,p.646-651
Nature Biotechnology,2005年,Vol.23, No.8,p.967-973

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei

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