Title:
心臓幹細胞
Document Type and Number:
Japanese Patent JP5202953
Kind Code:
B2
Abstract:
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity.
Inventors:
Murban edardo
Abraham Maria Roselle
Smith Rachel Earl.
Abraham Maria Roselle
Smith Rachel Earl.
Application Number:
JP2007540148A
Publication Date:
June 05, 2013
Filing Date:
November 08, 2005
Export Citation:
Assignee:
THE JOHNS HOPKINS UNIVERSITY
International Classes:
C12N5/077; A61K35/34; A61P9/00; C12N5/10; C12N15/09; A61K35/12
Foreign References:
| WO2001048151A1 | ||||
| WO2004044142A1 |
Other References:
Messina E et al.,Isolation and expansion of adult cardiac stem cells from human and murine heart.,Circ Res.,2004年10月 7日,Vol.95 no.9,pp.911-921
Beltrami AP et al.,Adult cardiac stem cells are multipotent and support myocardial regeneration.,Cell. ,2003年 9月19日,Vol.114 no.6,pp.763-776
Duff SE et al.,CD105 is important for angiogenesis: evidence and potential applications.,FASEB J. ,2003年 6月,Vol.17 no.9,pp.984-992
Beltrami AP et al.,Adult cardiac stem cells are multipotent and support myocardial regeneration.,Cell. ,2003年 9月19日,Vol.114 no.6,pp.763-776
Duff SE et al.,CD105 is important for angiogenesis: evidence and potential applications.,FASEB J. ,2003年 6月,Vol.17 no.9,pp.984-992
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi