Title:
新規なアセチルサリチル酸製剤
Document Type and Number:
Japanese Patent JP5232641
Kind Code:
B2
Abstract:
The invention relates to pharmaceutical compositions of acetylsalicylic acid-based microcapsules to selectively inhibit the COX in the portal vein and/or in the liver to reduce the production of thromboxane. Further, the pharmaceutical composition minimizes COX inhibition in the systemic circulation to optimize the inhibition of platelet aggregation. Certain embodiments also address methods of prevention and/or treatment of these diseases, using these oral compositions such as enhancing the safety of antithrombotic treatments. Other embodiments contemplate oral pharmaceutical compositions that combine acetylsalicylic acid with anti-platelet aggregation drugs, without inducing gastric side effects.
Inventors:
Sula, Gerard
Gimbert, Florence
Gimbert, Florence
Application Number:
JP2008512954A
Publication Date:
July 10, 2013
Filing Date:
May 24, 2006
Export Citation:
Assignee:
FLAMEL TECHNOLOGIES
International Classes:
A61K31/616; A61K9/58; A61K9/62; A61K45/00; A61K47/10; A61K47/12; A61K47/14; A61K47/32; A61K47/34; A61K47/38; A61K47/44; A61P7/02; A61P43/00; A61P9/10; A61P29/00
Domestic Patent References:
| JP7138164A | ||||
| JP10509427A | ||||
| JP3141224A |
Foreign References:
| WO2003057166A1 |
Attorney, Agent or Firm:
Katsuhiro Ito
Akiko Ono
Akiko Ono