Title:
V様ドメイン結合分子
Document Type and Number:
Japanese Patent JP5272257
Kind Code:
B2
Abstract:
The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
Inventors:
Gregory Coir
Maria Galanis
Peter John Hudson
Robert Alexander Iaving
Stewart Douglas Nuttall
Maria Galanis
Peter John Hudson
Robert Alexander Iaving
Stewart Douglas Nuttall
Application Number:
JP2011028861A
Publication Date:
August 28, 2013
Filing Date:
February 14, 2011
Export Citation:
Assignee:
Cephalon Australia (VIC) Pty Limited
International Classes:
C12N15/09; G01N33/50; A61K38/00; A61K39/395; A61P43/00; C07K14/665; C07K14/705; C07K14/73; C07K14/745; C07K16/00; C07K16/30; C07K16/40; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/70; G01N33/15; G01N33/566; G01N33/68
Other References:
J. Immunol., (1993), 150, [6], p.2281-2294
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro