Title:
レニン阻害剤としての3,5-置換ピペリジン化合物
Document Type and Number:
Japanese Patent JP5306821
Kind Code:
B2
Abstract:
The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (= disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3, 5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The compounds (which can also be present as salts) have the formula I'
wherein R1, R2, T, R3, R4, R7 and R8 are as defined in the specification and R6 is OH.
Inventors:
Takeshi Ehara
Philip Groshe
Osamu Irie
Iwaki Snow
Takaki Kanazawa
Shinpei Kawakami
Konishi Kago
Moteto Mogi
Yuki Suzuki
Yokokawa Fumiaki
Philip Groshe
Osamu Irie
Iwaki Snow
Takaki Kanazawa
Shinpei Kawakami
Konishi Kago
Moteto Mogi
Yuki Suzuki
Yokokawa Fumiaki
Application Number:
JP2008547900A
Publication Date:
October 02, 2013
Filing Date:
December 28, 2006
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D211/60; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D413/14; C07D471/04; A61K31/445; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/4709; A61K31/538; A61K31/55; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/22; A61P25/28; A61P27/06; A61P43/00
Domestic Patent References:
| JP2003529571A | ||||
| JP2000500502A |
Foreign References:
| WO2005051911A1 | ||||
| WO2005061457A1 |
Other References:
DANIELI,B. et al,An expeditious synthesis of dimethyl 1-benzyl-cis-piperidine-3,5-dicarboxylate,Synthetic Communications,1997年,Vol.27, No.1,p.69-77
Yonggang Chen et al,A Highly Enantioselective Catalytic Desymmetrization of Cyclic Anhydrides with Modified Cinchona Alkaloids,Journal of the American Chemical Society,2000年,Vol.122, No.39,p.9542-9543
Shi-Kai Tian et al,Asymmetric Organic Catalysis with Modified Cinchona Alkaloids,Accounts of Chemical Research,2004年,Vol.37, No.8,p.621-631
Carsten Bolm et al,Simple and Highly Enantioselective Nonenzymatic Ring Opening of Cyclic Prochiral Anhydrides,Synlett,1999年,No.2,p.195-196
Carsten Bolm et al,Practical and Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides Mediated by Cinchona Alkaloids,The Journal of Organic Chemistry,2000年,Vol.65, No.21,p.6984-6991
PARK J-S,TETRAHEDRON LETTERS,NL,ELSEVIER,2003年 2月17日,V44 N8,P1611-1614
DANIELI,BRUNO,SYNTHETIC COMMUNICATIONS,1997年,V27 N1,P69-77
Yonggang Chen et al,A Highly Enantioselective Catalytic Desymmetrization of Cyclic Anhydrides with Modified Cinchona Alkaloids,Journal of the American Chemical Society,2000年,Vol.122, No.39,p.9542-9543
Shi-Kai Tian et al,Asymmetric Organic Catalysis with Modified Cinchona Alkaloids,Accounts of Chemical Research,2004年,Vol.37, No.8,p.621-631
Carsten Bolm et al,Simple and Highly Enantioselective Nonenzymatic Ring Opening of Cyclic Prochiral Anhydrides,Synlett,1999年,No.2,p.195-196
Carsten Bolm et al,Practical and Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides Mediated by Cinchona Alkaloids,The Journal of Organic Chemistry,2000年,Vol.65, No.21,p.6984-6991
PARK J-S,TETRAHEDRON LETTERS,NL,ELSEVIER,2003年 2月17日,V44 N8,P1611-1614
DANIELI,BRUNO,SYNTHETIC COMMUNICATIONS,1997年,V27 N1,P69-77
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi