Title:
心臓脈管疾患のための医薬としてのアンドロスタンおよびアンドロステンのアザヘテロシクリル誘導体
Document Type and Number:
Japanese Patent JP5438502
Kind Code:
B2
Abstract:
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
Inventors:
Alberto Celli
Giorgio Fedrizi
Alessandra Beniccio
Giuseppe Bianchi
Patrizia Ferrari
Mauro Gobbini
Rosa Maria Micheletti
Marco Pozzi
Clown Enrico Scotty
Giorgio Fedrizi
Alessandra Beniccio
Giuseppe Bianchi
Patrizia Ferrari
Mauro Gobbini
Rosa Maria Micheletti
Marco Pozzi
Clown Enrico Scotty
Application Number:
JP2009504740A
Publication Date:
March 12, 2014
Filing Date:
April 11, 2007
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
C07J43/00; A61K31/58; A61P9/10; A61P9/12; A61P13/12; A61P43/00
Domestic Patent References:
| JP2007512279A | ||||
| JP2002536455A | ||||
| JP10077292A |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga