To provide a method for producing cadaverine by a continuous fermentation method for stably maintaining high productivity under simple operating conditions, and over a long time.
This method for producing cadaverine by a continuous fermentation method comprises separating a culture liquid into a filtrate and a non-filtrated liquid with a separation membrane, recovering cadaverine of desired fermentation product from the filtrate, and then by holding or returning the non-filtrated liquid in the culture liquid. By using a porous membrane having a high permeability and a high cell-stopping rate and hardly occluded as the separation membrane and by subjecting the culture liquid to filtration treatment at low inter-membrane difference pressure, the fermentation production efficiency of cadaverine can be improved markedly, in a stable manner and at low cost.
COPYRIGHT: (C)2008,JPO&INPIT
Hideki Sawai
Katsunari Yamada
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