Title:
非配列相補性の抗ウイルス性オリゴヌクレオチド
Document Type and Number:
Japanese Patent JP5514179
Kind Code:
B2
Abstract:
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antivral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.
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Inventors:
Bayan Andrew
Gute Jean-Marc
Gute Jean-Marc
Application Number:
JP2011251360A
Publication Date:
June 04, 2014
Filing Date:
November 17, 2011
Export Citation:
Assignee:
Replicor Incorporated
International Classes:
A61K31/7125; C12N15/09; A61K9/127; A61K31/7088; A61K31/713; A61K45/00; A61K45/06; A61K48/00; A61P25/00; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; C12N15/11; C12N15/115; C12Q1/70; A61K38/00
Domestic Patent References:
| JP8500738A |
Foreign References:
| WO2001002559A1 |
Other References:
CHENG,Y.C. et al,NUCLEOSIDES&NUCLEOCIDES,1991年,Vol.10,p.165-166
STEIN,C.A. et al,Antisense oligonucleotides as therapeutic agents--is the bullet really magical?,Science,1993年,Vol.261, No.5124,p.1004-12
LEITER,J.M.E. et al,Proc Natl Acad Sci,1990年,Vol.87,p.3430-3434
DIABATA,M. et al,Antisense oligodeoxynucleotides against the BZLF1 transcript inhibit induction of productive Epstein,Antiviral Res,1996年,Vol.29, No.2-3,p.243-60
TOLOU,H. et al,Partial inhibition of yellow fever virus replication in vitro with different phosphorothioate oligod,Acta Virol,1996年,Vol.40, No.2,p.73-9
STEIN,C.A. et al,Antisense oligonucleotides as therapeutic agents--is the bullet really magical?,Science,1993年,Vol.261, No.5124,p.1004-12
LEITER,J.M.E. et al,Proc Natl Acad Sci,1990年,Vol.87,p.3430-3434
DIABATA,M. et al,Antisense oligodeoxynucleotides against the BZLF1 transcript inhibit induction of productive Epstein,Antiviral Res,1996年,Vol.29, No.2-3,p.243-60
TOLOU,H. et al,Partial inhibition of yellow fever virus replication in vitro with different phosphorothioate oligod,Acta Virol,1996年,Vol.40, No.2,p.73-9
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa