Title:
４ＩＧ−Ｂ７−Ｈ３およびその対応するＮＫ細胞受容体を標的化する治療および診断方法ならびに組成物
Document Type and Number:
Japanese Patent JP5560301
Kind Code:
B2
Abstract:
The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.
Inventors:
Alessandro Moretta
Roberta Castries Koni
Christina ボッティーノ
Lorenzo Moretta
Roberta Castries Koni
Christina ボッティーノ
Lorenzo Moretta
Application Number:
JP2012138816A
Publication Date:
July 23, 2014
Filing Date:
June 20, 2012
Export Citation:
Assignee:
Inert ファルマソシエテアノニムINNATE PHARMA PHARMA S. A.
Sea urchin ヴェルシタ Di Genoa UNIVERSITA DI GENOVA
Sea urchin ヴェルシタ Di Genoa UNIVERSITA DI GENOVA
International Classes:
A61K39/395; A61P35/00; A61P35/02; C07K14/705
Attorney, Agent or Firm:
Mitsuo Tanaka
Yamasaki 宏
Norifumi Tomita
Yamasaki 宏
Norifumi Tomita