Title:
５９位にアミノ酸置換を有するインスリン様増殖因子−１（ＩＧＦ−１）の類似体
Document Type and Number:
Japanese Patent JP5571186
Kind Code:
B2
Abstract:
The present invention relates to novel analogues of insulin-like growth factor-1 (IGF-1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1-receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-1 having an amino acid substitution at position 59, e.g., (Asn59)hIGF-1(1-70)-OH (SEQ ID NO:1), and other substitution(s) as defined herein.
Inventors:
A boss, Tseng Singh
Prairie, Nicolas See
ウフレト, Mary El
Chang, Jun Don
Rosman, Deborah
Comstock, Jeanne Mary
Prairie, Nicolas See
ウフレト, Mary El
Chang, Jun Don
Rosman, Deborah
Comstock, Jeanne Mary
Application Number:
JP2012521623A
Publication Date:
August 13, 2014
Filing Date:
July 22, 2010
Export Citation:
Assignee:
Ibsen ファルマ ソシエテ Pearl Axion サンプリフィエIPSEN PHARMA S. A. S.
International Classes:
C07K14/65; A61K38/27; A61P1/04; A61P1/14; A61P3/04; A61P3/10; A61P3/12; A61P5/06; A61P7/00; A61P9/00; A61P19/00; A61P25/00; A61P27/02; A61P29/00; A61P43/00
Attorney, Agent or Firm:
Ono Shinjiro
Kobayashi 泰
Shigeo Takeuchi
Yamamoto 修
Hiroko Ejiri
Kobayashi 泰
Shigeo Takeuchi
Yamamoto 修
Hiroko Ejiri