Title:
ネトリン−１活性を用いた抗癌化合物のスクリーニング
Document Type and Number:
Japanese Patent JP5602368
Kind Code:
B2
Abstract:
The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells.
Inventors:
Patrick, Meylan
Agnes, Borne
Julianne, フィタマン
Agnes, Borne
Julianne, フィタマン
Application Number:
JP2008556779A
Publication Date:
October 08, 2014
Filing Date:
February 28, 2007
Export Citation:
Assignee:
サントル, a ナショ knurl, ド, ラ, ルシェルシュ, cyanogen tee フィク (セーエヌエルエス),
サントル Leon Berar
サントル Leon Berar
International Classes:
G01N33/574; A61K38/00; A61K45/00; A61P35/00; A61P43/00; G01N33/15; G01N33/50; C12N15/09
Attorney, Agent or Firm:
Katsunuma Hirohito
Yukitaka Nakamura
Nobutaka Yokota
Omori Michiko
Yukitaka Nakamura
Nobutaka Yokota
Omori Michiko