Title:
クリングルドメインの構造を基盤としたタンパク質骨格ライブラリー及びその用途
Document Type and Number:
Japanese Patent JP5616890
Kind Code:
B2
Abstract:
There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the structural scaffold of a Kringle domain; and protein scaffold variants, based on the Kringle domain structure, which modulate the biological activities of a variety of target molecules derived from the protein scaffold library by specifically binding to the target molecules. Also, there is provided a method for constructing homo-/hetero-oligomers which allow multi-specificity binding to multiple targets by the tandem assembly monomeric Kringle domain variants using a linker. Additionally, there is provided a method for preparing multispecific monomers and multivalent monomers by grafting target-binding loops of a Kringle domain variant into non-binding loops of another Kringle domain variant with the same or different target binding specificity. Furthermore, a protein scaffold variant based on the Kringle domain structure that specifically binds to target molecules, DNA encoding the protein scaffold variant, or a method and composition for prevention, detection, diagnosis, treatment or relieving diseases or disorders, particularly cancers and other immune-related diseases, comprising: administering an effective amount of the related molecule to animals, preferably human.
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Inventors:
キム、ヨン‐スン
クォン、ミョン‐ヒ
リ、チャン‐ハン
クォン、ミョン‐ヒ
リ、チャン‐ハン
Application Number:
JP2011522899A
Publication Date:
October 29, 2014
Filing Date:
August 07, 2009
Export Citation:
Assignee:
アジョウ・ユニバーシティ・インダストリー−アカデミック・コーポレイション・ファウンデイションＡＪＯＵ ＵＮＩＶＥＲＳＩＴＹ ＩＮＤＵＳＴＲＹ−ＡＣＡＤＥＭＩＣ ＣＯＯＰＥＲＡＴＩＯＮ ＦＯＵＮＤＡＴＩＯＮ
International Classes:
C12N15/09; C07K14/47; C12N15/01; C40B40/10
Attorney, Agent or Firm:
Patent business corporation ユニアス international patent firm