Title:
筋肉由来前駆体組成物を利用する骨の増大およびその処理
Document Type and Number:
Japanese Patent JP5624461
Kind Code:
B2
Abstract:
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
Inventors:
ペイン， トーマス
プルーチニク，ライアン
ジャンコウスキ， ロナルド
プルーチニク，ライアン
ジャンコウスキ， ロナルド
Application Number:
JP2010510329A
Publication Date:
November 12, 2014
Filing Date:
May 29, 2008
Export Citation:
Assignee:
ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション
International Classes:
A61K35/34; A61P19/08; C12N5/077; A61K35/12
Attorney, Agent or Firm:
Shusaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita