置換ナフチリジン及びＳＹＫキナーゼ阻害剤としてのその使用

Japanese Patent JP5629331

B2

The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6, R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.

ホフマン，マティアス
ダーマン，ゲオルク
フィーゲン，デニス
ハントシュー，サンドラ
クリシク，ヤスナ
リンツ，ギュンター
シャエンツレ，ゲルハルト
シューナップ，アンドレーアス
イースト，スティーヴン・ピー
マザネッツ，マイケル・フィリップ
スコット，ロバート・ジョン
ウォーカー，エドワード

JP2012550404A

November 19, 2014

January 21, 2011

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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング

C07D471/04; A61K31/4375; A61K31/4545; A61K31/4725; A61K31/496; A61K31/5377; A61K31/5383; A61K45/00; A61P1/04; A61P1/16; A61P7/00; A61P7/06; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P27/14; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D519/00

Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Ito 佐保子
Keiko Ozawa
Toshio Miyake
Yasuhiro Kokuni
Yoko Tanaka
Atsushi Shiomi
Saito a fringe -- happy

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