Title:
阻害性オリゴヌクレオチドを送達するための組成物および方法
Document Type and Number:
Japanese Patent JP5667043
Kind Code:
B2
Abstract:
The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.
Inventors:
アリャ，ビラ
オークハヌド，ピュレヴドルジ
エスピノザ，ホアン
オークハヌド，ピュレヴドルジ
エスピノザ，ホアン
Application Number:
JP2011505154A
Publication Date:
February 12, 2015
Filing Date:
April 15, 2009
Export Citation:
Assignee:
アメリカ合衆国ＧＯＶＥＲＮＭＥＮＴ ＯＦ ＴＨＥ ＵＮＩＴＥＤ ＳＴＡＴＥＳ ＯＦ ＡＭＥＲＩＣＡ， ａｓ ｒｅｐｒｅｓｅｎｔｅｄ ｂｙ ＴＨＥ ＳＥＣＲＥＴＡＲＹ， ＤＥＰＡＲＴＭＥＮＴ ＯＦ ＨＥＡＬＴＨＡＮＤ ＨＵＭＡＮ ＳＥＲＶＩＣＥＳ
International Classes:
C12N15/09; A61K38/00; A61K48/00; C07K14/08; C07K14/52; C07K19/00; C12N15/113
Attorney, Agent or Firm:
Seiji Kuzuwa